Metabolic engineering has been developed over the past 20 years to become an important tool for the rational engineering of industrial microorganisms. This book has a particular interest in the methods and applications of metabolic engineering to improve the production and yield of a variety of different metabolites. The overall goal is to achieve a better understanding of the metabolism in different microorganisms, and provide a rational basis to reprogram microorganisms for improved biochemical production.

1. Towards Synthetic Gene Circuits with Enhancers: Biology's Multi-input Integrators. -2. Elementary Mode Analysis: A Useful Metabolic Pathway Analysis Tool for Reprograming Microbial Metabolic Pathways. -3. Evolutionary Engineering for Industrial Microbiology. -4. Monitoring Microbial Diversity of Bioreactors Using Metagenomic Approaches. -5. Synthetic Biology Triggers New Era of Antibiotics Development. -6. Cascades and Networks of Regulatory Genes That Control Antibiotic Biosynthesis. -7. Systems Analysis of Microbial Adaptations to Simultaneous Stresses. -8. Metabolic Reprogramming under Microaerobic and Anaerobic Conditions in Bacteria. -9. Tunable Promoters in Synthetic and Systems Biology. -10. Analysis ofCorynebacterium glutamicum Promoters and Their Applications. -11. Production of Fumaric Acid by Fermentation. -12. Metabolic Engineering of Microorganisms for Vitamin C Production. -13. Molecular Mechanisms and Metabolic Engineering of Glutamate Overproduction inCorynebacterium glutamicum. -14. Microbial Metabolic Engineering for L-threonine Production. -15. The Production of Coenzyme Q10 in Microorganisms. -16. Genetic Modification and Bioprocess Optimization for S-adenosyl-L-methionine biosynthesis. -17. Manipulation ofRalstonia eutropha Carbon Storage Pathways to Produce Useful Bio-based Products. -18. Metabolic Engineering of Inducer Formation for Cellulase and Hemicellulase Gene Expression inTrichoderma reesei. -19. Microbiologically Produced Carboxylic Acids Used as Building Blocks in Organic Synthesis.