Life is produced by the interplay of water and biomolecules. This book deals with the physicochemical aspects of such life phenomena produced by water and biomolecules. All sections have been written by internationally recognized front-line researchers.

Kunihiro Kuwajima is Professor of Biophysical Chemistry at the Okazaki Institute for Integrative Bioscience. He also serves as a professor at the Institute for Molecular Science and at the Graduate University for Adavanced Studies (SOKENDAI). His major research interests are protein folding and molecular chaperones.Yuji Goto is Professor of Protein Science at the Institute for Protein Research, Osaka University. His major research interests are protein folding and misfolding including amyloid fibril formation.Fumio Hirata is Professor of Theoretical Chemistry at the Institute for Molecular Science. He also serves as a professor at the Graduate University for Adavanced Studies (SOKENDAI). His major interests are molecular theory of chemical processes in solution.Mikio Kataoka is Professor of Biophysics at the Graduate School of Materials Science at Nara Institute of Science and Technology. He also serves as a group leader of Neutron Biophysics Group at the Japan Atomic Energy Agency. His major research interests are the molecular basis of protein folding and functioning. He is also interested in the photoenergy conversion mechanism of light absorbing proteins.

1. Mapping Protein Folding Landscapes by NMR Relaxation.- 2. Experimental and Simulation Studies on the Folding/Unfolding of Goat a-Lactalbumin.- 3. Transition in the Higher-order Structure of DNA in Aqueous Solution.- 4. Generalized-Ensemble Algorithms for Studying Protein Folding.- 5. Protein Folding and Binding: Effective Potentials, Replica Exchange Simulations, and Network Models.- 6. Functional Unfolded Proteins: How, When, Where and Why?.- 7. Structure of the Photointermediate of Photoactive Yellow Protein and the Propagation Mechanism of Structural Change.- 8. Time-resolved Detection of Intermolecular Interaction of Photosensor Proteins.- 9. Volumetric Properties of Proteins and the Role of Solvent in Conformational Dynamics.- 10. A Statistical Mechanics Theory of Molecular Recognition.- 11. Computational Studies of Protein Dynamics.- 12. Biological Functions of Trehalose as a Substitute for Water.- 13. Life on the Edge: The Origins and Proliferation of Protein Misfolding Diseases.- 14. Effect of Light on Amyloidogenic Proteins: Nucleation and Fibril Extension.- 15. Real-time Observation of Amyloid Fibril Growth by Total Internal Reflection Fluorescence Microscopy.

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