Stem cell research can not only develop potential sources of cells for endocrine therapy, but can also allow the study of organ development ex vivo using isolated and defined stem cell precursors. In Stem Cells in Endocrinology, leading stem cell biologists and developmental endocrinologists critically review both cutting-edge approaches to stem cell biology and the application of stem cells to endocrine diseases, including diabetes, infertility, and liver-associated metabolic disorders. The authors discuss current research to modify stem cells, develop an endocrine-like cell, and use adult bone marrow stem cells to treat autoimmune diseases, including endocrine-based autoimmune diseases. Topics of interest include a review of all stem cell subtypes and their characteristics, approaches to promoting endocrine development from stem cells, and evidence for endocrine cell function from stem cells. The authors also outline how best to develop preclinical studies that will determine the safety and efficacy of stem cell therapies for endocrine disorders. Background chapters provide a basic understanding of stem cell biology and introduce all major types of stem cells, including embryonic, adult, cord blood, and germ line. State of the art and forward looking, Stem Cells in Endocrinology offers the basic and clinician scientist an authoritative evaluation of all aspects of how stem cells might be used to create endocrine cells and to treat such diseases as type 1 diabetes.

Leseprobe

Part I: Basic Stem Cell Biology Embryonic Stem Cells: Derivation, Properties, and Therapeutic Implications Victoria L. Browning and Jon S. Odorico Germ Line Stem Cells Makoto C. Nagano Umbilical Cord Stem Cells Kathy E. Mitchell Differentiation Potential of Adult Stem Cells Henry E. Young and Asa C. Black, Jr. Growth Conditions for Primate vs Murine Embryonic Stem Cells Gillian M. Beattie, Nathan Bucay, Rohan Humphrey, Ana D. Lopez, and Alberto Hayek Part II: Translational Research Islet Precursor Cells in Adult Pancreatic Islets Gladys Teitelman and Irem Nasir Transcription Factor-Directed Differentiation of Stem Cells Along an Endocrine Lineage William L. Lowe, Jr. Generation of Islet-Like Structures From ES Cells Nadya Lumelsky The Therapeutic Potential of Liver Repopulation for Metabolic or Endocrine Disorders Sanjeev Gupta The Manipulation of Mesenchymal Stem Cells for Bone Repair Shelley R. Winn Spermatogenesis From Transplanted Spermatogenic Stem Cells Michael D. Griswold and Derek McLean Hematopoietic Stem Cell Transplant in the Treatment of Autoimmune Endocrine Disease Jody Schumacher and Ewa Carrier Preclinical Trials for Stem Cell Therapy Linda B. Lester, K. Y. Francis Pau, and Don P. Wolf Index

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