The Nidoviruses

Toward Control of SARS and other Nidovirus Diseases, Advances in Experimental Medicine and Biology 581

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Bibliografische Daten
ISBN/EAN: 9781441938749
Sprache: Englisch
Umfang: xxxviii, 618 S., 218 s/w Illustr., 3 farbige Illus
Auflage: 1. Auflage 2006
Einband: kartoniertes Buch

Beschreibung

InhaltsangabeViral RNA Synthesis.- The Coronavirus Replicase: Insights into a Sophisticated Enzyme Machinery.- Biochemical Aspects of Coronavirus Replication.- A Previously Unrecognized Unr Stem-Loop Structure in the Coronavirus 5' Untranslated Region Plays a Functional role in Replication.- Regulation of Coronavirus Transcription: Viral and Cellular Proteins Interacting with Transcription-Regulating Sequences.- Deubiquitinating Activity of the SARS-CoV Papain-Like Protease.- Nucleocapsid Protein Expression Facilitates Coronavirus Replication.- Non Structural Proteins 8 and 9 of Human Coronavirus 229E.- Effects of Mutagenesis of Murine Hepatitis Virus NSP1 and NSP14 on Replication in Culture.- Mutational Analysis of MHV-A59 Replicase Protein-NSP10.- The NSP2 Proteins of Mouse Hepatitis Virus and Sars Coronavirus are Dispensable for Viral Replication.- Molecular Dissection of Porcine Reproductive and Respiratory Virus Putative Nonstructural Protein 2.- Differential role of N-Terminal Polyprotein Processing in Coronavirus Genome Replication and Minigenome Amplification.- Identification and Characterization of Severe Acute Respiratory Syndrome Coronavirus Subgenomic RNAs.- Identification and Characterization of a Unique Ribosomal Frameshifting Signal in SARS-CoV ORF3A.- Adp-Ribose-1"-Phosphatase Activities of the Human Coronavirus 229E and Sars Coronavirus X Domains.- Nonstructural Proteins of Human Coronavirus NL63.- MHV-A59 Orf1a Replicase Protein NSP7-NSP10 Processing in Replication.- Stem-Loop 1 in the 5' UTR of the Sars Coronavirus can Substitute for its Counterpart in Mouse Hepatitis Virus.- Transcriptional Regulation of RNA3 of Infectious Bronchitis Virus.- Protein Synthesis, Structure, and Processing.- Structure, Expression, and Intracellular Localization of the SARS-CoV Accessory Proteins 7a and 7b.- Sumoylation of the Nucleocapsid Protein of Severe Acute Respiratory Syndrome Coronavirus by Interaction with UBC9.- Importance of MHV-CoV A59 Nucleocapsid Protein Cooh-Terminal Negative Charges.- Expression and Structural Analysis of Infectious Bronchitis Virus Nucleoprotein.- Mouse Hepatitis Virus Infection Activates the IRE1/XBP1 Pathway of the Unfolded Protein Response.- The Nuclear Localization Signal of the Prrs Virus Nucleocapsid Protein Modulates Viral Replication in vitro and Antibody Response in vivo.- Sars Coronavirus Accessory ORFs Encode Luxury Functions.- Production and Characterization of Monoclonal Antibodies Against the Nucleocapsid Protein of SARS-COV.- Mouse Hepatitis Coronavirus Nucleocapsid Phosphorylation.- Viral Assembly and Release.- Genetic and Molecular Biological Analysis of Protein-Protein Interactions in Coronavirus Assembly.- New Insights on the Structure and Morphogenesis of Berne Virus.- Ultrastructure of SARS-CoV, FIPV, and MHV Revealed by Electron Cryomicroscopy.- Role of Mouse Hepatitis Coronavirus Envelope Protein Transmembrane Domain.- The Transmembrane Domain of the Infectious Bronchitis Virus E Protein is Required for Efficient Virus Release.- Viroporin Activity of SARS-CoV E Protein.- Efficient Transduction of Dendritic Cells Using Coronavirus-Based Vectors.- Viral Entry.- Insights from the Association of SARS-CoV S-Protein with its Receptor, ACE2.- Attachment Factor and Receptor Engagement of Sars Coronavirus and Human Coronavirus NL63.- Interactions Between Sars Coronavirus and its Receptor.- Proteolysis of Sars-Associated Coronavirus Spike Glycoprotein.- Fluorescence Dequenching Assays of Coronavirus Fusion.- Porcine Arterivirus Entry in Macrophages: Heparan Sulfate - Mediated Attachment, Sialoadhesin-Mediated Internalization, and a Cell-Specific Factor Mediating Virus Disassembly and Genome Release.- Enhancement of SARS-CoV Infection by Proteases.- Increased Viral Titers and Subtle Changes in Plaque Morphology Upon Passage of SARS-CoV in Cells from Different Species.- Human Coronavirus 229E can Use CD209L (L-Sign) to Enter Cells.- Intracellular Transport of the S Proteins of Coronaviruses.- Anal

Inhalt

Preface.- Protein Synthesis, Structure, and Processing.- Viral Assembly and Release.- Viral Entry 1 and 2.- Pathogenesis of Non-Human Coronaviruses.- Pathogenesis of Arteriviruses and Toroviruses.- Pathogenesis of Human Coronaviruses.- Vaccines, Anti-Viral Drugs, and Diagnostics.- Index.

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