Recent Advances In Retinal Degeneration

Advances in Experimental Medicine and Biology 613

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Bibliografische Daten
ISBN/EAN: 9781441925770
Sprache: Englisch
Umfang: xxxiv, 424 S., 114 s/w Illustr., 3 farbige Illustr
Auflage: 1. Auflage 2008
Einband: kartoniertes Buch

Beschreibung

InhaltsangabePreface.- About The Editors.- Travel Awardees.- Part I Keynote Lectures.- Curing Blindness With Stem Cells: Hope, Reality, And Challenges.- Retinal Degenerations: Planning For The Future.- Part Ii Neuroprotection.- Neurotrophins Induce Neuroprotective Signaling In The Retinal Pigment Epithelial Cell By Activating The Synthesis Of The Anti-Inflammatory And Anti-Apoptotic Neuroprotectin D1.- On The Role Of Cntf As A Potential Therapy For Retinal Degeneration.- Nanoceria Particles Prevent Roi-Induced Blindness.- An In-Vivo Assay To Identify Compounds Protective Against Light Induced Apoptosis.- Role Of Bcl-Xl In Photoreceptor Survival.- The Hypoxic Transcriptome Of The Retina.- Part Iii Gene Therapy And Neuroprotection.- Lentiviral Gene Transfer-Mediated Cone Vision Restoration In Rpe65 Knockout Mice.- In Vitro Analysis Of Ribozyme-Mediated Knockdown Of An Adrp Associated Rhodopsin Mutation.- Gene Therapy For Mouse Models Of Adrp.- Development Of Viral Vectors With Optimal Transgene Expression For Ocular Gene Therapies.- Adeno-Associated Viral Vectors And The Retina.- Genetic Supplementation Of Rds Alleviates A Loss-Of-Function Phenotype In C214s Model Of Retinitis Pigmentosa.- Morphological Aspects Related To Long-Term Functional Improvement Of The Retina In The 4 Years Following Raav-Mediated Gene Transfer In The Rpe65 Null Mutation Dog.- Virus-Mediated Gene Delivery To Neuronal Progenitors.- Part Iv Animal Models Of Retinal Degeneration.- Loss Of Visual And Retinal Function In Light-Stressed Mice.- Erg Responses And Microarray Analysis Of Gene Expression In A Multifactorial Murine Model Of Age-Related Retinal Degeneration.- Oxygen Supply And Retinal Function: Insights From A Transgenic Animal Model.- Characterization Of Gene Expression Profiles Of Normal Canine Retina And Brain Using A Retinal Cdna Microarray.- Toward A Higher Fidelity Model Of Amd.- The Potential Of Ambient Light Restriction To Restore Function To The Dengerating P23h-3 Rat Retina.- Part V Molecular Genetics And Candidate Genes.- Mutations In Known Genes Account For 58% Of Autosomal Dominant Retinitis Pigmentosa (Adrp).- Genetics Of Age-Related Macular Degeneration.- Retinal Phenotype Of An X-Linked Pseudo-Usher Syndrome In Association With The G173r Mutation In The Rpgr Gene.- Mutation In The Pyk2-Binding Domain Of Pitpnm3 Causes Autosomal Dominant Cone Dystrophy (Cord5) In Two Swedish Families.- Identification And Characterization Of Genes Expressed In Cone Photoreceptors.- Clinical And Genetic Characterization Of A Chinese Family With Csnb1.- 10q26 Is Associated With Increased Risk Of Age-Related Macular Degeneration In The Utah Population.- Part Vi Diagnostic, Clinical, Cytopathological And Physiologic Aspects Of Retinal Degeneration.- Carboxyethylpyrrole Adducts, Age-Related Macular Degeneration And Neovascularization.- A Possible Impaired Signaling Mechanism In Human Retinal Pigment Epithelial Cells From Patients With Macular Degeneration.- Expression and Cell Compartmentalization of Efemp1, A Protein Associated with Malattia Leventinese.- Role of Elovl4 in Fatty Acid Metabolism.- Organization and Molecular Interactions of Retinoschisin in Photoreceptors.- Part VII Basic Science Underlying Retinal Degeneration.- Proteomics Profiling of the Cone Photoreceptor Cell Line, 661W.- G -Secretase Regulates Vegfr-1 Signalling in Vascular Endothelium and RPE.- Analysis of the Rate of Disk Membrane Digestion by Cultured RPE Cells.- Functional Expression of Cone Cyclic Nucleotide-Gated Channel in Cone Photoreceptor-Derived 661W Cells.- Phosphorylation of Caveolin-1 in Bovine Rod Outer Segments in Vitro by an Edogenous Tyrosine Kinase.- Regulation of Neurotrophin Expression and Activity in the Retina.- Involvement of Guanylate Cyclases in Transport of Photoreceptor Peripheral Membrane Proteins.- Rod Progenitor Cells in the Mature Zebrafish Retina.- Avß5 Integrin Receptors at the Apical Surface of The RPE: One Receptor, Two Functions.- Implantation of Mouse Eyes w

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