Principles of Toxicology concisely and efficiently presents the scientific basis for toxicology as it applies to the workplace and the environment, covering diverse chemical hazards encountered in modern workplaces and natural environments and providing a practical understanding of these hazards for those concerned with protecting the health of humans and ecosystems. The work presents not only theory, but also practical information regarding chemical hazards to give the student and new professional a working knowledge of the practice of toxicology and the ability to solve problems in environmental and industrial settings.

Case histories and examples from industrial and environmental exposures to chemicals are included to demonstrate the application of toxicological principles. To allow for seamless reader comprehension and further exploration of covered topics, the work is supplemented with numerous illustrations to clarify and summarize key points, as well as annotated bibliographies. In the 4th edition, all chapters and references have been updated to account for the latest scientific thinking, and new color figures have been added.

New topics covered in 4th Edition ofPrinciples of Toxicology include:Regulatory toxicology, including the key regulatory framework in which much of the field of toxicology operatesAlternative methods in toxicology, including cutting-edge approaches to developing new information on the toxicity of drugs and chemicals The dilemma of selecting safe exposure limits, guiding readers through practical considerations and pitfalls in developing and using safe exposure limitsEcological risk assessment, with detailed discussion of methods and considerations when evaluating the effects of contaminants on plants and animals.

Providing information on the principles of toxicology and the application of those principles to solve problems in environmental and industrial settings,Principles of Toxicology serves as an excellent textbook resource for advanced undergraduate, graduate, and professional students in a range of environmental and health fields. It is also valuable to health professionals who need toxicological information and assistance beyond what is found in an introductory text to general toxicology.

Stephen M. Roberts, PhD,is Professor and Program Director of the Center for Environmental and Human Toxicology at the University of Florida, Gainesville, FL.

Robert C. James, PhD, is Senior Science Advisor, ToxStrategies, Boise, ID.

Phillip L. Williams, PhD,is Dean and Professor Emeritus, College of Public Health, University of Georgia, Athens, GA.

1 General Principles of Toxicology
Robert C. James, Stephen M. Roberts, and Phillip L. Williams

2 Xenobiotic Absorption, Distribution, Metabolism and Excretion
Michael R. Franklin

3 Toxicokinetics
Rebecca A. Clewell and Harvey J. Clewell III

4 Regulatory Toxicology
Raymond M. David

5 Alternative Methods in Toxicity Testing
Leona D. Scanlan, XuefeiCao, and Christopher D. Vulpe

6 ComputationalToxicology
Richard S. Judson, David M. Reif, Keith A. Houck, Thomas B. Knudsen, Joshua Harrill, Katie Paul Friedman

7 Hematotoxicity:Toxic Effects on the Hematopoietic System
Lila Ramaiah, Tara Arndt, and Michelle Cora

8 Hepatotoxicity: Toxic Effects on the Live
Robert C. James and Stephen M. Roberts

9 Nephrotoxicity: Toxic Effects on the Kidney
Lawrence H. Lash

10 Neurotoxicology: Toxic Effects on the Nervous System
W. Michael Caudle, Meghan Bucher, Alexandria C. White, and Gary W. Miller

11 Dermal Toxicology: Toxic Effects on the Skin
Sailesh Konda and Howard I Maibach

12 Pulmonotoxicity: Toxic Effects on the Respiratory System
Cuiqing Liu and Qinghua Sun

13 Immunotoxicity: Toxic Effects on the Immune System
Eric S. Sobel and Stephen M. Roberts

14 Reproductive and Developmental Toxicity: Toxic Effects on the Female and Male Reproductive Tracts and Offspring
Shuo Xiao, Krista Symosko, and Charles A. Easley IV

15 Mutagenesis and Genetic Toxicology
Martha M. Moore, Meagan B. Myers and Robert H. Heflich

16 Chemical Carcinogenesis
James E. Klaunig, Luma Melo, and Karen Tilmant

17 Properties and Effects of Metals
David B. Mayfield, Lisa A. Bailey, Joel M. Cohen, and Barbara D. Beck

18 Pesticides
Janice Britt

19 Properties and Toxicology of Organic Solvents and Solvent-Like Chemicals
Christopher M. Teaf and Michele M. Garber

20 Nanotoxicology
Hongbo Ma and Stephen M. Roberts

21 Insights into Epidemiology
J. Fryzek, C. Frankenfeld, N. Movva, L. Bylsma, and J. Acquavella

22 Occupational and Environmental Health
Laura Breeher, Fredric Gerr, and T. Rene Anthony

23 Human Health Risk Assessment
Leah D. Stuchal

24 Ecological Risk Assessment
Brett Thomas

25 The Dilemma of Selecting Safe Exposure Values
Robert C. James, Phillip L. Williams,and Stephen M. Roberts