Inhaltsangabe1. ETIOLOGY OF NARCOLEPSYEtiology and genetics of human narcolepsy Emmanuel Mignot Narcolepsy: autoimmunity or secondary to infection? Adriano Fontana, Heidemarie Gast, Thomas  Birchler Is narcolepsy a neurodegenerative disorder? Christelle Peyron  2. NEUROCHEMISTRY OF NARCOLEPSYThe roles of hypocretin/orexin in narcolepsy, Parkinson's disease, and normal behaviour Jerome Siegel Histamine in narcolepsy and excessive daytime sleepiness Seiji Nishino Dopaminergic substrates underlying hypersomnia, sleepiness, and REM sleep expression David B. Rye, Amanda A.H. Freeman The serotoninergic system in sleep and narcolepsy Chloé Alexandre, Thomas E. Scammell Sleep homeostasis, adenosine, caffeine, and narcolepsy HansPeter Landolt Prostaglandin D2: an endogenous somnogen Yoshihiro Urade, Osamu Hayaishi   3. THE ROLE OF THE HYPOCRETINS IN SLEEP-WAKE REGULATIONThe neurobiology of sleep-wake systems: an overview PierreHervé Luppi, Patrice Fort The hypocretins/orexins: master regulators of arousal and hyperarousal Matthew E. Carter, Antoine Adamantidis, Luis de Lecea Optogenetic probing of hypocretin/orexin regulation of wakefulness Antoine Adamantidis, Luis de Lecea Hypocretin/orexin receptor functions in mesopontine systems regulating sleep, arousal and cataplexy Christopher S. Leonard, Mike Kalogiannis, Kristi A. Kohlmeier Afferent control of the hypocretin/orexin neurons Thomas S. Kilduff, Junko Hara, Takeshi Sakurai, Xinmin Xie  The neural basis of sleepiness in narcoleptic mice Thomas E. Scammell, Chloé Alexandre Mathematical models of narcolepsy Cecilia Diniz Behn    4. THE KEY ROLE OF THE HYPOTHALAMUSThe hypothalamus and its functions Giovanna Zoccoli, Roberto Amici, Alessandro Silvani  The prehistory of orexin/hypocretin and melanin-concentrating hormone neurons of the lateral hypothalamus Clifford B. Saper Metabolic influence on the hypocretin/orexin neurons Denis Burdakov Endocrine abnormalities in narcolepsy Thomas Pollmächer. Marietta Keckeis, Andreas Schuld Appetite and obesity Alice Engel, Norbert Dahmen  5. REWARD, ADDICTION, EMOTIONS AND THE HYPOCRETIN SYSTEMEffects of orexin/hypocretin on ventral tegmental area dopamine neurons: an emerging role in addiction Stephanie L. Borgland Orexin/hypocretin, drug addiction, and narcolepsy Ralph J. DiLeone, Maysa Sarhan, Ruth Sharf Emotional processing in narcolepsy Sophie Schwartz Depression in narcolepsy Michael Lutter  6. REM SLEEP DYSREGULATION AND MOTOR ABNORMALITIES IN NARCOLEPSYThe clinical features of cataplexy Sebastiaan Overeem Parasomnias in narcolepsy with cataplexy Yves Dauvilliers, Régis Lopez The motor system and narcolepsy: Periodic leg movements and restless leg syndrome Luigi Ferini Strambi   7. THE BORDERLANDS OF NARCOLEPSYSpectrum of narcolepsy Claudio Bassetti Secondary narcolepsy Philipp O. Valko, Rositsa Poryazova Posttraumatic narcolepsy Christian R. Baumann, Rositsa PoryazovaThe hypocretin/orexin system and sleepiness in Parkinson's disease Rolf Fronczek Idiopathic hypersomnia Ramin Khatami  8. THE DIAGNOSIS OF NARCOLEPSY AND THE ASSESSMENT OF FITNESS TO DRIVECurrent diagnostic criteria of adult narcolepsy Alex Iranzo The arguments for standardized diagnostic procedures Geert Mayer Fitness to drive in narcolepsy Johannes Mathis 9. TREATMENT OF NARCOLEPSYTreatment of narcolepsy Gert Jan Lammers Treatment of narcolepsy in the childMichel Lecendreux

Christian R. Baumann, MD University Hospital of Zurich, SwitzerlandClaudio L. Bassetti, MD University Hospital of Zurich, SwitzerlandThomas E. Scammell, MD Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, USA

1. ETIOLOGY OF NARCOLEPSY Etiology and genetics of human narcolepsy Emmanuel Mignot  Narcolepsy: autoimmunity or secondary to infection? Adriano Fontana, Heidemarie Gast, Thomas  Birchler  Is narcolepsy a neurodegenerative disorder? Christelle Peyron  2. NEUROCHEMISTRY OF NARCOLEPSY The roles of hypocretin/orexin in narcolepsy, Parkinson¿s disease, and normal behaviour Jerome Siegel  Histamine in narcolepsy and excessive daytime sleepiness Seiji Nishino  Dopaminergic substrates underlying hypersomnia, sleepiness, and REM sleep expression David B. Rye, Amanda A.H. Freeman  The serotoninergic system in sleep and narcolepsy Chloe Alexandre, Thomas E. Scammell  Sleep homeostasis, adenosine, caffeine, and narcolepsy Hans-Peter Landolt  Prostaglandin D2: an endogenous somnogen Yoshihiro Urade, Osamu Hayaishi   3. THE ROLE OF THE HYPOCRETINS IN SLEEP-WAKE REGULATION The neurobiology of sleep-wake systems: an overview Pierre-Herve Luppi, Patrice Fort  The hypocretins/orexins: master regulators of arousal and hyperarousal Matthew E. Carter, Antoine Adamantidis, Luis de Lecea  Optogenetic probing of hypocretin/orexin regulation of wakefulness Antoine Adamantidis, Luis de Lecea  Hypocretin/orexin receptor functions in mesopontine systems regulating sleep, arousal and cataplexy Christopher S. Leonard, Mike Kalogiannis, Kristi A. Kohlmeier  Afferent control of the hypocretin/orexin neurons Thomas S. Kilduff, Junko Hara, Takeshi Sakurai, Xinmin Xie   The neural basis of sleepiness in narcoleptic mice Thomas E. Scammell, Chloe Alexandre  Mathematical models of narcolepsy Cecilia Diniz Behn    4. THE KEY ROLE OF THE HYPOTHALAMUS The hypothalamus and its functionsGiovanna Zoccoli, Roberto Amici, Alessandro Silvani   The prehistory of orexin/hypocretin and melanin-concentrating hormone neurons of the lateral hypothalamus Clifford B. Saper  Metabolic influence on the hypocretin/orexin neurons Denis Burdakov  Endocrine abnormalities in narcolepsy Thomas Pollmächer. Marietta Keckeis, Andreas Schuld  Appetite and obesity Alice Engel, Norbert Dahmen  5. REWARD, ADDICTION, EMOTIONS AND THE HYPOCRETIN SYSTEM Effects of orexin/hypocretin on ventral tegmental area dopamine neurons: an emerging role in addiction Stephanie L. Borgland  Orexin/hypocretin, drug addiction, and narcolepsy Ralph J. DiLeone, Maysa Sarhan, Ruth Sharf  Emotional processing in narcolepsy Sophie Schwartz  Depression in narcolepsy Michael Lutter  6. REM SLEEP DYSREGULATION AND MOTOR ABNORMALITIES IN NARCOLEPSY The clinical features of cataplexy Sebastiaan Overeem  Parasomnias in narcolepsy with cataplexy Yves Dauvilliers, Regis Lopez  The motor system and narcolepsy: Periodic leg movements and restless leg syndrome Luigi Ferini Strambi    7. THE BORDERLANDS OF NARCOLEPSY Spectrum of narcolepsy Claudio Bassetti  Secondary narcolepsy Philipp O. Valko, Rositsa Poryazova  Posttraumatic narcolepsy Christian R. Baumann, Rositsa Poryazova The hypocretin/orexin system and sleepiness in Parkinson¿s disease Rolf Fronczek  Idiopathic hypersomnia Ramin Khatami  8. THE DIAGNOSIS OF NARCOLEPSY AND THE ASSESSMENT OF FITNESS TO DRIVE Current diagnostic criteria of adult narcolepsy Alex Iranzo  The arguments for standardized diagnostic procedures Geert Mayer  Fitness to drive in narcolepsy Johannes Mathis  9. TREATMENT OF NARCOLEPSY Treatment of narcolepsy Gert Jan Lammers  Treatment of narcolepsy in the childMichel Lecendreux