InhaltsangabeThermal Transition Spectroscopy: A New Tool for Submolecular Investigation of Biologic Macromolecules.- I. Introduction.- II. Results.- III. Application of the Method to the Study of DNA-Containing Complexes.- References.- Interactions of Drugs with Liver Microsomes.- I. Introduction.- II. Structural and Chemical Organization of Liver Microsomes.- III. Interaction of Drugs with the Microsomal Lipid Fraction.- IV. Interactions of Drugs with Microsomal Proteins.- V. Effects of Drugs on Microsomal Constitution and Activities.- VI. Summary and Concluding Remarks.- References.- The Pathogenesis of Experimental Acute Renal Failure: The Role of Membrane Dysfunction.- I. Introduction.- II. Heavy Metal-Induced Alterations in Membrane Function.- III. The Renin-Angiotensin System.- IV. Renal Hemodynamics and Acute Renal Failure.- V. Synthesis.- References.- Three-Dimensional Pharmacophoric Pattern Searching.- I. Introduction.- II. Quantitative Structure-Activity Relationships.- III. Description of Pharmacophoric Patterns.- IV. Three-Dimensional Pharmacophoric Pattern Searching.- V. Pattern Matching Applications.- VI. Conclusions.- References.- Chemical Evolution: A Terrestrial Reassessment.- I. Introduction.- II. Development of the Terrestrial Environment.- III. Further Chemical Evolutionary Hierarchies.- IV. Terrestrial Life: Chance or Circumstance.- V. Conclusion.- References.- Supplementary Bibliography.

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