Handbook of Treatment-resistant Schizophrenia is a concise review of treatment-resistant schizophrenias definition, measurement tools, adherence issues, substance abuse, optimal dosing, clinicianpatient relationships, and current management approaches. The book was originally commissioned with the intention of creating a comprehensive text focusing on treatment-resistant schizophrenia and its management. The book explores many aspects of the background and practice- and research-based evidence for treating this complex subset of schizophrenia, including psychopharmacological, somatic, and nonpharmacological treatment approaches. While exploring the various therapies for treatment-resistant schizophrenia, Dr Citrome also emphasizes the importance of building strong and trusting relationships between patients and their clinicians so the clinician can best manage their patients adherence and overall treatment.

Leslie Citrome is Clinical Professor of Psychiatry& Behavioral Sciences at New York Medical College, Valhalla, NY, USA, and was the founding Director of the Clinical Research and Evaluation Facility at the Nathan S. Kline Institute for Psychiatric Research in Orangeburg, NY, USA. He is the author or coauthor of over 400 research reports, reviews, chapters, and abstracts in the scientific literature. He is the Deputy Editor and incoming Editor-in-Chief for the International Journal of Clinical Practice, serves on the editorial board of six other medical journals, reviews for over 50 journals, and has lectured extensively throughout the United States, Canada, Europe, and Asia.

Introduction.- A general treatment approach.- Adherence the great masquerade of treatment-resistance.- Dosing of antipsychotics what evidence do we use?.- Psychopharmacological approaches.- Somatic treatments.- Nonpharmacological approaches.- Conclusions.