Movement is the way that animals interact with their environment and is under the organization and complex control of the brain and spinal cord. Multiple central nervous systems, including cortex, basal ganglia, cerebellum, and brainstem, interact to provide precise motor control and integration. Damage or disease within these systems cause profound motor disturbances in man, which can be effectively modeled in animals to develop a better understanding and treatment of the human condition. Animal Models of Movement Disorders introduces a variety of methods and techniques used to model and assess motor function in experimental animals from lower orders, such as drosophila and c. elegans, through vertebrate species including fish, to mammals, such as rodents and non-human primates. The most advanced contemporary models in each system are presented at multiple levels of analysis from molecular and genetic modeling, lesions, anatomy, neurochemistry, to imaging and behavior. Volume I contains general methods of movement disorder assessment as well as an extensive section on dopamine systems.  Comprehensive and meticulous, Animal Models of Movement Disorders serves as a valuable reference for those studying motor disorders by covering methodologies in detail and providing the information necessary to consider both the appropriate models and assessment tools that can most informatively answer the key experimental issues in the field.

Part I: Generic Methods of Assessment   1. Why Can¿t a Rodent Be More like a Man?: A Clinical Perspective             Anne E. Rosser   2. Zebrafish as a Vertebrate Model Organism for Studying Movement Disorders             Maria Sundvik and Pertti Panula   3. Methodological Strategies to Evaluate Functional Effectors Related to Parkinson¿s Disease through Application of C. elegans Models             Kim A. Caldwell and Guy A. Caldwell   4. Effects of Alpha-Synuclein Expression on Behavioral Activity in Drosophila, a Simple Model of Parkinson¿s Disease             Robert G. Pendleton, Xiaoyun C. Yang, Natalie Jerome, Ornela Dervisha, and Ralph Hillman   5. Neurological Evaluation of Movement Disorders in Mice             Simon Brooks   6. Rodent Skilled Reaching for Modeling Pathological Conditions of the Human Motor System             Jenni M. Karl and Ian Q. Whishaw   7. High Throughput Mouse Phenotyping             Sabine M. Hölter and Lisa Glasl   8. MRI of Neurological Damage in Rats and Mice             Mathias Hoehn   9. Quantification of Brain Function and Neurotransmission System In Vivo by Positron Emission Tomography: A Review of Technical Aspects and Practical Considerations in Preclinical Research             Nadja Van Camp, Yann Bramoulle, and Philippe Hantraye   10. Optical Approaches to Studying the Basal Ganglia             Joshua L. Plotkin, Jaime N. Guzman, Nicholas Schwarz, Geraldine Kress, David L. Wokosin, and D. James Surmeier   11. Electrophysiological Analysis of Movement Disorders in Mice             Shilpa P. Rao, Veronique M. Andre, Carlos Cepeda, and Michael S. Levine   Part II: Dopamine Systems   12. Genetic Models of Parkinsons Disease             Ralf Kühn, Daniela Vogt-Weisenhorn, and Wolfgang Wurst   13. 6-OHDA Lesion Models of Parkinson¿s Disease in the Rat             Eduardo M. Torres and Stephen B. Dunnett   14. 6-OHDA Toxin Model in Mouse             Gaynor A. Smith and Andreas Heuer   15. Rotation in the 6-OHDA Lesioned Rat             Stephen B. Dunnett and Eduardo M. Torres   16. Of Rats and Patients: Some Thoughts about Why Rats Turn in Circles and Parkinson¿s Disease Patients Cannot Move Normally             Gordon W. Arbuthnott   17. Comparing Behavioral Assessment of Sensorimotor Function in Rat and Mouse Models of Parkinson¿s Disease and Stroke             Sheila M. Fleming and Timothy Schallert   18. Rodent Models of L-DOPA-Induced Dyskinesia             Hanna S. Lindgren and Emma L. Lane   19. Using the MPTP Mouse Model to Understand Neuroplasticity: A New Therapeutic Target for Parkinson¿s Disease?             Giselle M. Petzinger, Beth E. Fisher, Garnik Akopian, Ruth Wood, John P. Walsh, and Michael W. Jakowec   20. The MPTP Treated Primate, with Specific Reference to the Use of the Common Marmoset (C. jacchus)             Michael J. Jackson and Peter Jenner   21. Behavioral Assessment in the African Green Monkey after MPTP Administration             D. Eugene Redmond, Jr.