Written by experts in the field, Principles and Practice of Skin Toxicology provides a "bottom up" approach to studying skin toxicology. It provides a clear outline of basic concepts, citing both historical and modern references, and contains a glossary of key terms for quick and easy reference. Arranged in a user friendly and logical sequence, the book covers the five main areas of dermatotoxicology: * Principles of skin absorption. Explains the factors influencing dermal absorption and associated methods of measurement. * Methods for assessing skin toxicity. An overview of both in vivo and in vitro approaches to testing, with particular emphasis on the validation and use of alternative test strategies. * Clinical and occupational skin toxicity. A basic introduction to dermatology and related applications central to understanding dermal exposure to chemicals. * Regulatory aspects. An overview of national and international legislation governing the safe marketing of pharmaceuticals, cosmetics and industrial chemicals. This book will be especially useful to scientists who are new to the area of dermal toxicology, as well as practitioners of toxicology, clinical researchers, and researchers in industry and academia.

Leseprobe

Contents Foreword Preface Acknowledgements List of contributors PART I Introduction 1 Cutaneous anatomy and function Robert P. Chilcott Summary References 2 Biochemistry of the skin Simon C. Wilkinson Summary References 3 Skin photobiology Mark A. Birch-Machin and Simon C. Wilkinson Summary References PART II Skin Absorption 4 Skin as a route of entry Simon C. Wilkinson Summary References 5 Physicochemical Factors Affecting Skin Absorption Keith R. Brain and Robert P. Chilcott Summary References 6 Principles of Diffusion and Thermodynamics W. John Pugh and Robert P. Chilcott Summary References 7 In vivo measurements of skin absorption James C. Wakefield and Robert P. Chilcott Summary References 8 In vitro percutaneous absorption measurements Ruth U. Pendlington Summary References PART III Toxicological Assessment 9 Skin immunology and sensitisation David A. Basketter Summary References 10 In vitro phototoxicity assays Penny Jones Summary References 11 In vitro alternatives for irritation and corrosion assessment Penny Jones Summary References 12 Instruments for measuring skin toxicity Helen Taylor Summary References PART IV Clinical Aspects 13 Introduction to dermatology Manjunatha Kalavala and Alex Anstey Summary 14 Clinical aspects of phototoxicity Anthony D. Pearse and Alex Anstey Summary References 15 Occupational skin diseases Jon Spiro Summary References 16 Prevention of occupational skin disease Chris Packham Summary References PART V Regulatory 17 Occupational skin exposures: legal aspects Chris Packham Summary References 18 Safety assessment of cosmetics: an EU perspective Jo Larner Summary References Appendix 18.1 Additional obligations for cosmetic suppliers 19 Regulatory dermatotoxicology and international guidelines Adam Woolley Summary References 20 Glossary of main terms and abbreviations James C. Wakefield Index